“The happiest five cities are all in Louisiana, with Lafayette taking the crown (Louisiana is also the happiest state). The unhappiest cities, after New York City, are St. Joseph, Mo.; South Bend, Ind.; Erie, Penn.; and the Evansville, Ind.-Henderson, Ky. area.”
The five happiest cities are, in order, Lafayette, Houma, Shreveport-Bossier, Baton Rouge and Alexandria. Lake Charles is #8 and Monroe is #17. New Orleans is #57, if I counted correctly.
Compare and contrast (Presidential voting results 2012, from Wikipedia Commons):