“The happiest five cities are all in Louisiana, with Lafayette taking the crown (Louisiana is also the happiest state). The unhappiest cities, after New York City, are St. Joseph, Mo.; South Bend, Ind.; Erie, Penn.; and the Evansville, Ind.-Henderson, Ky. area.”

The five happiest cities are, in order, Lafayette, Houma, Shreveport-Bossier, Baton Rouge and Alexandria. Lake Charles is #8 and Monroe is #17. New Orleans is #57, if I counted correctly.

Source: http://blogs.marketwatch.com/capitolreport/2014/07/18/new-york-city-is-the-most-unhappy-city-in-america/

Compare and contrast (Presidential voting results 2012, from Wikipedia Commons):